Skip to Main content Skip to Navigation
Journal articles

A Similar Speciation Process Relying on Cellular Stochasticity in Microbial and Cancer Cell Populations

Abstract : Similarities between microbial and cancer cells were noticed in recent years and serve as a basis for an atavism theory of cancer. Cancer cells would rely on the reactivation of an ancestral "genetic program" that would have been repressed in metazoan cells. Here we argue that cancer cells resemble unicellular organisms mainly in their similar way to exploit cellular stochastiity to produce cell specialization and maximize proliferation. Indeed, the relationship between low stochasticity, specialization, and quiescence found in normal differentiated metazoan cells is lost in cancer. On the contrary, low stochasticity and specialization are associated with high proliferation among cancer cells, as it is observed for the "specialist" cells in microbial populations that fully exploit nutritional resources to maximize proliferation. Thus, we propose a model where the appearance of cancer phenotypes can be solely due to an adaptation and a speciation process based on initial increase in cellular stochasticity.
Document type :
Journal articles
Complete list of metadatas

Cited literature [105 references]  Display  Hide  Download

https://hal.inrae.fr/hal-02982941
Contributor : Suzette Astruc <>
Submitted on : Thursday, October 29, 2020 - 10:49:06 AM
Last modification on : Friday, October 30, 2020 - 3:29:36 AM

File

2020_Capp_iScience.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Jean-Pascal Capp, Frédéric Thomas. A Similar Speciation Process Relying on Cellular Stochasticity in Microbial and Cancer Cell Populations. iScience, Elsevier, 2020, 23 (9), pp.1-12. ⟨10.1016/j.isci⟩. ⟨hal-02982941⟩

Share

Metrics

Record views

47

Files downloads

19