THREE-DIMENSIONAL CARDIAC REMODELLING AFTER RESTORATION TO SINUS RHYTHM IN ATRIAL FIBRILLATION: ONE YEAR FOLLOW UP

Laurie Soulat-Dufour (1, 2, 3) , Sylvie Lang (2, 1, 3) , Karima Addetia (1, 2, 3) , Stephane Ederhy (2, 1, 3) , Saroumadi Adavane-Scheuble (2, 1, 3) , Marion Chauvet-Droit (2, 1, 3) , Marie-Liesse Jean (2, 1, 3) , Pascal Nhan (2, 1, 3) , Rim Ben Said (2, 1, 3) , Iris Kamami (2, 1, 3) , Pauline Issaurat (2, 1, 3) , Victor Mor-Avi (2, 1, 3) , Franck Boccara (2, 1, 3) , Roberto Lang (2, 1, 3) , Ariel Cohen (2, 1, 3)

1 The University of Chicago Medicine [Chicago]
2 CHU Saint-Antoine [AP-HP]
3 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases

Background: The long-term four-chamber cardiac remodelling after sinus rhythm restoration in atrial fibrillation is unknown. Methods: We prospectively evaluated 86 consecutive patients hospitalized for atrial fibrillation. Three-dimensional indexed volumes (3D Vi) and ejection fraction of the right (RA) left atria (LA) right (RV) and left ventricle (LV) were measured using transthoracic echocardiography at admission and at 12 months follow-up. Patients were divided into two groups according to restoration of sinus rhythm (n=47) or persistence of atrial fibrillation (n=39) post cardioversion, ablation or pharmacological therapy. Results: Compared to baseline values at one year the 3D Vi of both atria were smaller at ED and ES. in the sinus group. Interestingly, the RV was significantly smaller only in ES and unchanged in ED whereas the LV was larger in ED and unchanged is ES (Figure A). At one year the 3D ejection fraction of all cardiac chambers were improved (Figure C). In contrast, in the atrial fibrillation group at 12 months, there were no significant differences in 3D Vi of RA, LV and LA end-systolic Vi together with a significant increase of 3D RV Vi and LA end-diastolic Vi (Figure B). No significant changes in ejection fraction were noted in the RA, RV and LV but with a significant decrease LA ejection fraction (Figure D). Conclusion: The management of atrial fibrillation should be focused on restoration of sinus rhythm to improve cardiac remodelling and both atrial and ventricular ejection fractions.

Domaines: Cardiologie et système cardiovasculaire

Laurie Soulat-Dufour, Sylvie Lang, Karima Addetia, Stephane Ederhy, Saroumadi Adavane-Scheuble, et al.. THREE-DIMENSIONAL CARDIAC REMODELLING AFTER RESTORATION TO SINUS RHYTHM IN ATRIAL FIBRILLATION: ONE YEAR FOLLOW UP. Journal of the American College of Cardiology, 2021, 77 (18, Suppl 1), pp.1414. ⟨10.1016/S0735-1097(21)02772-8⟩. ⟨hal-03222297⟩