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Preprints, Working Papers, ...

PI4P and BLOC-1 remodel endosomal membranes into tubules

Abstract : ABSTRACT Intracellular trafficking is mediated by transport carriers that originate by membrane remodeling from donor organelles. Tubular carriers play major roles in the flux of membrane lipids and proteins to acceptor organelles. However, how lipids and proteins impose a tubular geometry on the carriers is incompletely understood. By exploiting imaging approaches at different scales on cells and in vitro membrane systems, we show that phosphatidylinositol-4-phosphate (PI4P) and biogenesis of lysosome-related organelles complex 1 (BLOC-1) govern the formation, stability and functions of recycling endosomal tubules. Endosomal PI4P production by type II PI4-kinases is needed to form nascent curved tubules through binding of BLOC-1 that stabilize and elongate them. Membrane remodeling by the PI4P/ BLOC-1 module functions not only in the recycling of endosomal cargoes, but also in the lifecycles of intracellular pathogens such as Chlamydia bacteria and influenza virus. This study demonstrates how a phospholipid and a protein complex coordinate as a minimal machinery to remodel cellular membranes into functional tubes.
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Preprints, Working Papers, ...
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Contributor : Patricia Bassereau Connect in order to contact the contributor
Submitted on : Saturday, November 27, 2021 - 5:42:15 PM
Last modification on : Tuesday, January 4, 2022 - 6:06:16 AM
Long-term archiving on: : Monday, February 28, 2022 - 6:30:36 PM


BioRxiv-2021.10.21.465321v1 (1...
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Riddhi Atul Jani, Aurélie Di Cicco, Tal Keren-Kaplan, Silvia Vale-Costa, Daniel Hamaoui, et al.. PI4P and BLOC-1 remodel endosomal membranes into tubules. 2021. ⟨hal-03452929⟩



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