Skip to Main content Skip to Navigation
Journal articles

Cancer risk from chronic exposures to chemicals and radiation: a comparison of the toxicological reference value with the radiation detriment

Abstract : This article aims at comparing reference methods for the assessment of cancer risk from exposure to genotoxic carcinogen chemical substances and to ionizing radiation. For chemicals, cancer potency is expressed as a toxicological reference value (TRV) based on the most sensitive type of cancer generally observed in animal experiment of oral or inhalation exposure. A dose-response curve is established by modelling experimental data adjusted to apply to human exposure. This leads to a point of departure from which the TRV is derived as the slope of a linear extrapolation to zero dose. Human lifetime cancer risk can then be assessed as the product of dose by TRV and it is generally considered to be acceptable below 10-5 for public in normal situation. Radiation exposure is assessed as effective dose corresponding to a weighted average of energy deposition in body organs. Cancer risk models were derived from the epidemiological follow-up of atomic bombing survivors. Considering a linear-no-threshold dose-risk relationship and average baseline risks, lifetime nominal risk coefficients were established for 13 types of cancers. Those are adjusted according to the severity of each cancer type and combined into an overall indicator denominated radiation detriment. Exposure to radiation is subject to dose limits proscribing unacceptable health detriment. The differences between chemical and radiological cancer risk assessments are discussed and concern data sources, extrapolation to low doses, definition of dose, considered health effects and level of conservatism. Despite these differences, opportunities exist to bring closer the two types of risk assessment.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-03348204
Contributor : Irsn Athena Connect in order to contact the contributor
Submitted on : Friday, September 17, 2021 - 9:00:37 PM
Last modification on : Tuesday, September 21, 2021 - 3:32:12 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2022-09-06

Please log in to resquest access to the document

Identifiers

Collections

Citation

Enora Clero, Michèle Bisson, Nathalie Velly, Eric Blanchardon, Eric Thybaud, et al.. Cancer risk from chronic exposures to chemicals and radiation: a comparison of the toxicological reference value with the radiation detriment. Radiation and Environmental Biophysics, Springer Verlag, 2021, ⟨10.1007/s00411-021-00938-2⟩. ⟨hal-03348204⟩

Share

Metrics

Record views

29