Ionizing radiation exposure during adulthood and risk of developing central nervous system tumors: systematic review and meta-analysis

Julie Lopes (1) , Clémence Baudin (1) , Klervi Leuraud (1) , Dmitry Klokov (2) , Marie-Odile Bernier (1)

1 IRSN/PSE-SANTE/SESANE/LEPID - Laboratoire d épidémiologie des rayonnements ionisants
2 IRSN/PSE-SANTE/SESANE/LRTOX - Laboratoire de radiotoxicologie et radiobiologie expérimentale

Abstract Many studies on ionizing radiation (IR) exposure during childhood have shown deleterious effects on the central nervous system (CNS), however results regarding adult exposure are inconsistent, and no systematic reviews have been performed. The objectives are to synthesize the findings and draw evidence-based conclusions from epidemiological studies on the risk of benign and malignant brain and CNS tumors in humans exposed to low-to-moderate doses (< 0.5 Gy) of IR during adulthood/young adulthood. A systematic literature search of four electronic databases, supplemented by a hand search, was performed to retrieve relevant epidemiological studies published from 2000 to 2022. Pooled excess relative risk (ERR pooled ) was estimated using a random effect model. Eighteen publications were included in the systematic review and twelve out of them were included in a meta-analysis. The following IR sources were considered: atomic bombs, occupational, and environmental exposures. No significant dose-risk association was found for brain/CNS tumors (ERR pooled at 100 mGy = − 0.01; 95% CI: − 0.05, 0.04). Our systematic review and meta-analysis did not show any association between exposure to low-to-moderate doses of IR and risk of CNS tumors. Further studies with histological information and precise dose assessment are needed.

Domaines: Statistiques [stat]

Julie Lopes, Clémence Baudin, Klervi Leuraud, Dmitry Klokov, Marie-Odile Bernier. Ionizing radiation exposure during adulthood and risk of developing central nervous system tumors: systematic review and meta-analysis. Scientific Reports, 2022, 12 (1), pp.16209. ⟨10.1038/s41598-022-20462-7⟩. ⟨irsn-03879491⟩